Soluble phosphate salts as setting aids for premixed calcium phosphate bone cement pastes

Recently, premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration. Use of saves the time removes an extra step during a medical operation. α-Tricalcium (α-TCP) based cements set to form deficient hydroxyapatite which has moderate bioresorbtion speed. α-TCP require setting aid, usually sodium or potassium salt, speed up process. Within current research we investigated aid significant advantage, if is used in non-aqueous paste. This approach offers application simple ingredients produce cement. The following properties formulations were evaluated: cohesion, phase composition, microstructure, pH value liquid surrounding cement, compressive strength. Compositions using mixture basic acidic salts (KH2PO4 K2HPO4) sufficient amounts give best overall results (adequate cohesion liquid, hydrolysis starting materials within 48 h, strength 12 ± 3 MPa). Cement prepared with salt (Na2HPO4) had considerably higher 22 1 MPa, but was (9.0).